精神分裂症首次发病患者的磁共振弥散张量显像研究

The white matter and grey matter in the first episodic schizophrenia: a diffusion tensor imaging study

目的探讨从未用过药的精神分裂症首次发病(以下简称首发)患者的重要白质及部分灰质区的磁共振弥散张量显像(DTI)的特点。方法选取9例首发精神分裂症患者(患者组)及9名年龄、性别、受教育程度与患者组相配对的健康者,应用DTI成像技术检测脑额颞交界处、内囊等白质区和颞中回灰质、中央前回、中央后回等灰质区的各向异性(FA)、表观扩散系数(ADC)及双侧海马体积。结果患者组及对照组组内左右两侧兴趣区FA值及ADC值的差异无统计学意义(P>0.05);患者组与对照组各感兴趣区FA值差异无统计学意义(P>0.05),但患者组颞中回灰质(8.655×10-9)、中央前回(7.816×10-9)、中央后回(7.855×10-9)ADC值高于对照组(分别为7.428×10-9,6.921×10-9,7.013×10-9;P=0.049,0.009,0.005);两组内及组间双侧海马体积比较,差异均无统计学意义(P>0.05)。结论首发精神分裂症患者与健康者DTI参数之间没有明显区别。

Objective This study was to measure white matter and grey matter in some brain regions of neuroleptics-free patients with first episodic schizophrenia using the diffusion tensor magnetic resonance imaging （ DTI）. Methods DTI was performen in a sample of 9 first episode schizophrenic patients and 9 gender-, age-, and education-matched controls. Regions of interest were placed in the relay of temporal and frontal lobe, internal capsule, hippocampus, precentral gyrus, and postcentral gyrus, and fractional anisotropy （FA） and apparent diffusion coefficient （ADC） were measured, Z- test was used to test group differences, with group as between-subjects factor and side as within-subjects factor. Results （ 1 ） No differences of FA and ADC in ROIs between left and right sides were found in both patients and controls （P 〉 0.05）. （2） There were no differences of FA in the ROIs between patients and controls （P 〉 0. 05 ）, while the ADR in the middle temporal lobe, precentral gyrus and postcentral gyrus were significantly higher in patients than in controls （P 〈 0. 05 ）. （3） There were no differences in the hippocampus volume between both the groups （ P 〉 0. 05 ）. Conclusions No difference of DTI parameters are found between the first episode schizophrenic patients and healthy controls in this study.