抑郁症患者血浆P物质含量变化及其相关性研究

The plasma concentration of substance P in depression before and after treatment

目的探讨抑郁症患者血浆P物质水平的变化及其与抑郁症的关系。方法对32例抑郁症患者(抑郁症组)应用帕罗西汀治疗6周,分别于治疗前和治疗后第6周末采用放射免疫法测定患者血浆P物质含量;同时以汉密尔顿抑郁量表(24项,HAMD)、汉密尔顿焦虑量表(18项,HAMA)评定症状严重程度,以HAMD减分率评定疗效。以32名健康志愿者为对照组。结果抑郁症组患者治疗前血浆P物质水平[(51±13)ng/L]明显高于对照组[(43±11)ng/L],差异有统计学意义(P=0.010);治疗后血浆P物质水平[(44±10)ng/L]较治疗前明显下降,差异有统计学意义(P=0.001);治疗前后血浆P物质的变化与HAMD总分值的减分率呈显著正相关(rs=0.826,P=0.000)。结论抑郁症患者的血浆P物质存在异常,动态观察血浆P物质水平变化可能有助于判断疗效。

Objective The aim of this study was to explore the change of plasma substance P in patients with depression, and the relationship between substance P and depressive symptoms. Methods Thirty-two depressed patients diagnosed with the 3rd edition of Chinese Classification and Diagnostic Criteria for Mental Disorders criteria were recruited and treated with paroxetine for 6 weeks, and 32 healthy volunteers recruited as controls. The plasma substance P was measured with radioimmunoassay before and after treatment. The severity of symptom was evaluated with the 24-item Hamilton Rating Scale for Depression （ HAMD-24）, and 18-item Hamilton Rating Scale for anxiety （ HAMA-18 ）. Results The plasma substance P level was significantly higher in patients before treatment than that in controls [ （51 ± 13） ng/L vs. （43 ± 11 ） ng,/L, P =0. 010], and significantly decreased after treatment [ （44 ± 10） ng/L, P = 0. 001 ]. There was significantly negative correlation between the reduction of plasma substance P and the reduction rate of HAMD-24 score （ r, = 0. 826, P = 0. 000）. Conclusion It suggests that the substance P might be involved in pathophysiology of depression, and dynamic observation of the plasma substance P level be possibly helpful to judge the therapeutic effect.