先天性心脏病手术前后血浆内皮素含量的测定及意义

Determination and Signification of the Preoperative and Postoperative Concentration of Plasma Endothelin in Congenital Heart Disease

采用放射免疫均相竞争法测定５０例先天性心脏病患儿手术前后血浆内皮素（ＥＴ）的含量。结果术前为（９９．４８±４５．６５）ｐｇ／ｍｌ，术后为（５１．１７±２２．５８）ｐｇ／ｍｌ，两者间有非常显著差异（Ｐ＜０．０１）。术前明显高于正常对照组（Ｐ＜０．０１），术后接近正常水平。实验结果表明，先心病的病理生理过程及疾病的进展过程中有促进ＥＴ升高的因素。它可能与肺动脉高压、肺血管内皮损伤、乏氧及心功能不全有关。术后由于畸型的纠正，心脏正常生理过程的恢复，ＥＴ水平也随之下降，恢复至正常。

he concentrations of the preoperative and postoperative plasma endothelin(ET)in 50 cases withcongenital heart disease were determined by radioimmunoassay. We found that the preoperative concen-tration of ET was 99.48 ± 45.64 pg/ml.The postoperative concentration was 51.17 ± 22.58 pg/ml.The difference between these two groups was statistically significant (P< 0.01).The results showedthat pathophysioIogical course of congenital heart disease and the progressive course of the diseasemight promote the increase of ET. It may be closely related to pulmonary hypertention,damage of pul-monary vascular endothelin cell,functional disorder of the heart,and chronic heart failure. With thecorrection of the malformation and recovery from abnormal physiological function of the heart,the con-centration of ET returned to normal.