期刊文献+

维生素E有什么希望?

Is There Any Hope for Vitamin E?
下载PDF
导出
摘要 过去15年来,有关动脉粥样硬化的流行病学、基础生物学和实验研究均支持下述假设:抗氧化剂可通过抑制动脉壁低密度脂蛋白的氧化而抑制动脉粥样硬化的发生。这种作用机制可抑制胆固醇酯通过巨噬细胞清除受体在动脉斑块内发生病理性沉积。胆固醇酯病理沉积是一种可引起斑块破裂及心血管事件的过程。同样,生物机制亦已确定,癌基因可被抗氧化剂阻断。
出处 《美国医学会杂志(中文版)》 2006年第2期124-126,共3页 The Journal of the American Medical Association(Chinese Edition)
  • 相关文献

参考文献38

  • 1Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC.Vitamin E consumption and the risk of coronary disease in women, N Engl J Med.1993 ;328:1444-1449
  • 2Rimm EB, Stampfer M J, Ascherio A, Giovannucci E, Colditz GA, Willett WC.Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328:1450-1456.
  • 3Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis.J Clin Invest, 1991;88:1785-1792.
  • 4Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radio Res Commun. 1989;6:67-75.
  • 5Parthasarathy S, Young SG, Witztum JL, Pittman RC, Steinberg D. Probucol inhibits oxidative modification of low density lipoprotein. J Clin Invest. 1986;77:641-644.
  • 6Sparrow CP, Doebber TW, Olszewski J, et al. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterolfed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine. J Clin Invest. 1992;89:1885-1891.
  • 7Carew TE, Schwenke DC, Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci U S A. 1987;84:7725-7729.
  • 8Sasahara M, Raines EW, Chait A, et al. Inhibition of hypercholesterolemiainduced atherosclerosis in the nonhuman primate by probucol I: is the extent of atherosclerosls related to resistance of LDL to oxidation? J Clin Invest. 1994 94:155-164.
  • 9Brown BG, Zhao XQ, Sacco DE, Albers J J, Lipid lowering and plaque regression: new insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 1993;87:1781-1791.
  • 10Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995;91:2844-2850.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部