摘要
哺乳动物神经系统的发育是一个复杂的过程,包含有多层次基因的表达与调节。P19胚胎瘤细胞系具有正常雄性小鼠染色体核型,在维甲酸的诱导下可向神经细胞方向分化,是研究神经发育机制的一个理想的细胞模型。本文就P19细胞、P19细胞的诱导、分化及参与P19细胞神经分化的相关因素做一综述。
The development of mammalian nervous system is a highly complex process involving regulation and coordination of gene expression at multiple steps. The embryonic carcinoma cell line P19 possesses normal karyotype of male mouse. It can differentiate into neurons when treated with retinoic acid. The P19 mouse embryonic carcinoma cell line is a suitable model system to analyze regulation of neuronal differentiation. In this review, characteristics of P19, neuronal differentiation of P19 and the relative factors involved are summarized.
出处
《军事医学科学院院刊》
CSCD
北大核心
2006年第2期176-179,共4页
Bulletin of the Academy of Military Medical Sciences
