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SGK在中枢神经系统疾病中的研究进展 被引量：3

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摘要 血清和糖皮质激素调节蛋白激酶(SGK)是一个与蛋白激酶B(PKB/AKT)等第二信使蛋白具有极高的同源性的丝/苏氨酸(Ser/Thr)蛋白激酶。调节机制与其他蛋白激酶显著不同,SGK除了受磷酸化/去磷酸化调节外,还存在快速转录水平上的调节机制。它可能作为多种细胞信号转导通路和细胞磷酸化级联反应的一个功能性交汇点,参与离子通道调节、细胞增殖、分化、存活及凋亡的信号转导,在中枢神经系统发育、神经元变性、凋亡过程中起重要作用。本文就SGK的结构、功能及其在中枢神经系统疾病中的研究进展作一综述。
作者 曹金霞 耿德勤
机构地区 徐州医学院附属医院神经内科
出处 《徐州医学院学报》 CAS 2006年第3期278-282,共5页 Acta Academiae Medicinae Xuzhou
关键词 血清和糖皮质激素调节蛋白激酶 信号转导 中枢神经系统疾病
分类号 R741.02 [医药卫生—神经病学与精神病学]
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参考文献21

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同被引文献27

  • 1王全胜,张晓丽,王玉梅,邓安国,朱忠华,冯玉锡.血清和糖皮质激素诱导的蛋白激酶在糖尿病肾病小鼠中的表达及意义[J].中华肾脏病杂志,2004,20(6):442-445. 被引量：16
  • 2帝振宇,赵青川,何勇,赵威.钠离子微电流探测仪在胆道肿瘤诊断中的应用[J].中国医学工程,2006,14(6):619-621. 被引量：3
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  • 8Becamel C, Galeotti N, Poncet J, et al. A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors [J]. Biol Proced Online, 2002,41(1):94-104.
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徐州医学院学报
2006年 第3期

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