头孢菌素类抗生素的核磁共振波谱特征

NMR spectroscopic characteristics of cephalosporins

目的阐述头孢菌素类抗生素的核磁共振波谱特征。方法应用1H-1H COSY、HMQC,HMBC等二维核磁共振技术对头孢噻吩钠等8个头孢菌素类抗生素进行了测试。结果在对8个头孢菌素类抗生素的1H NMR1、3C NMR信号进行全归属的基础上,对1H NMR谱偶合裂分、偶合常数及1H NMR1、3C NMR谱中取代基对化学位移的影响进行了分析,总结了头孢菌素类抗生素核磁共振波谱的特征。结论头孢菌素类抗生素母核的1H NMR和13C NMR谱有明显特征,取代基的变化对质子和碳的化学位移影响有一定规律。

Objective To summarize the NMR spectroscopic characteristics and regularities of cephalosprins. Methods The 2D-NMR techniques of ^1H-^1H COSY, HMQC and HMBC were used for detecting the eight cephalosprlns, such as cefalotin sodium. Results On the basis of the full assignments of the ^1H and 13C spectra of cephalosprins, systematic researchs were carried out on the splitting patterns and coupling constants in ^1H-NMR spectra, the effect of substituents on the chemical shifts in ^1H spectra and ^13C spectra. The spectroscopic characteristics and regularities of cephalosprins in NMR spectrum were summurized. Conclusions The spectroscopic characteristics of cephalosprins are summarized.