摘要
本文观察了45例青紫型先天性心脏病(CCHD)患儿血液流变学和血小板聚集功能的变化。结果显示:与对照组比较红细胞压积和全血粘度显著提高,红细胞聚集功能及刚性增强,变形运动能力减低,血小板聚集功能降低,纤维蛋白原减少,血浆比粘度增高。提示CCHD患儿存在着严重的血液流变学异常,不仅有血液粘度的变化,而且有血小板和红细胞的生理功能异常。本文对其临床意义进行了讨论。
This paper presents 45 cases of CCHD in which the changes of hcmorrheologic parameters including the blood viscosity. Red-cell indices and platelet aggregation were investigated. The results showed that the hematocrit(HCT), the blood viscosity under both high and low shear rates increased significantly (P <0.01). The platelet aggregation decreased greatly (P<CO. 01) ,the Red-cell indices of aggregation and rigidity increased markedly(P<0.01)with its transformation ability decreased significantly (P<0.01 ) in the severe cyanotic group. The differences between the severe and slight cyanotic groups were discussed at the same time. It was concluded that patients with CCHD have serious changes of several hemorrheologic parameters espically in the severe cyanotic group. Improving the hemorrheologic values is important, to prevent the complication.
