等容血液稀释和丹参对缺血再灌注心肌的保护作用

Protective Effects of Isovolumic Hemodilution and Danshen Solution on Ischemic Reperfused Myocardium

观察了右旋糖酐40等容血液稀释和复方丹参注射液对犬急性缺血再灌注心肌的影响。结果:单用右旋糖酐40或丹参可使±dp/dt—max较对照组明显升高(P<0.05).两组间虽无明显差异.前者发挥作用较快。二者合用不仅使±dp/dt—max、LVSP较对照组明显升高(P<0.05),而且较单用右旋糖酐或丹参组明显升高(P<0.05),心肌丙二醛含量降低,梗塞范围缩小。提示:①右旋糖酐40等容血液稀释和复方丹参注射液对缺血再灌注心肌功能有保护作用,前者发挥作用较快。②二者并用有良好的协同作用。

This paper reports the effects of isovolumic hemodilution and Danshen solution on acute is-chemic reperfused canine myocardium. The results showed that either Dextron 40 or Danshen solution alone induced a significant increase in 眃p/dt-max compared with the control group(P<0. 05). Though there existed no significant difference between the two groups before the treatment, the former showed more rapid action. The combination of the two therapies improved ndp/dt-max and LVSP, and significantly reduced the necrotic size and the MDA contents in the ischemic myocardium in comparison with not only the control group but also the Dextron 40 group or the Danshen group (P<0.05). The results suggest that isovolumic hemodilution with Dextron 40 or Danshen may protect the ischemic reperfused myocarium and the former may come into action more rapidly, and that the combination of the two may show a better synergism than the single one only.