Delta N p63蛋白在膀胱癌组织中的表达及意义

Expression and clinical significance of delta N p63 protein in bladder transitional cell cancer

目的:探讨DeltaNp63(ΔNp63)蛋白在膀胱移行细胞癌(TCCB)中的表达及意义。方法:采用SP免疫组织化学法检测43例TCCB患者肿瘤组织、11例对照组膀胱组织ΔNp63蛋白的表达,并分析ΔNp63蛋白表达与TCCB临床分期、病理分级的关系。结果:43例TCCB组织中ΔNp63蛋白表达阳性率为100%(43/43),对照组膀胱组织中ΔNp63蛋白表达的阳性率为18.2%(2/11),TCCB组ΔNp63蛋白表达的阳性率明显高于正常组,差异有显著性(P<0.05)。不同临床分期肿瘤组织中ΔNp63蛋白表达的阳性率及强度,各组间ΔNp63蛋白表达的阳性率及表达强度差异无显著性(P>0.05)。不同病理分级肿瘤组织中ΔNp63蛋白表达的阳性率及强度,各组间ΔNp63蛋白表达的阳性率及表达强度差异无显著性(P>0.05)。结论:TC-CB组ΔNp63蛋白表达水平均明显高于正常组,提示ΔNp63与TCCB的发生密切相关,可能为TCCB发生的重要促进因素,ΔNp63蛋白表达水平与TCCB的临床分期、病理分级没有相关性,故ΔNp63在TCCB进展中的作用有待进一步研究。

Objective： to explore the expression and clinical significance of delta N p63 protein in transitional cell carcinoma oI mebladder （ TCCB ）. Method： The immunohistochemical staining assay was conducted to detect expression of delta N p63 protein in 43 cases of TCCB and 11 cases of normal bladder epithelium. The relationship between delta N p63 protein expression and pathological types ,clinical stages of TCCB was analyzed. Results：The expression rates of delta N p63 protein in TCCB and normal bladder epithelium were100% （ 43/43 ） and 15.2% （ 2/11 ） respectively. The difference between the two groups was significant （ P〈 0.05 ）. There was no significant difference in the expression rate of deha N p63 protein in different pathological types and clinical stages of TCCB, The differences between groups were no significant. Conclusion：There is high expression of delta N p63 protein in TCCB, deha N p63 is associated withtumorigenesis in TCCB, but is not associated with pathological types and clinical stages of TCCB. Further studies will be necessary to explore the function of delta N p63 in the progression of TCCB.