摘要
去唾液酸糖蛋白受体(ASGPR)是哺乳动物肝细胞表面的特异性受体,肝硬化和肝癌时ASGPR水平下降。利用99mTcGSA进行该受体的显像,能够得到HH15、LHL15、[R]0、R0等指标用于肝功能的评估;将这种功能性显像与单光子发射型计算机断层显像(SPECT)技术相结合,可以模拟肝脏切除的范围,并预测术后剩余肝脏的功能。此技术在国际上是一个新的课题,在国内尚无开展,用它来数字化的评估手术风险对患者手术方式的选择及预后具有重要影响。笔者结合正在进行的这方面部分研究,向读者作一介绍,以期在临床上发挥更好的作用。
Asialoglycoprotein receptor （ASGPR） is a specific receptor of mammalian hepatocytes. Reduction in ASGPR concentration has been proven to appear in liver cirrhosis and liver cancer. By liver ASGPR scintigraphy with ^99mTcGSA, some indexes such as HH15 ,LHL15, [ R] 0 ,R0 can be obtained, which is useful for the evaluation of liver function. When combining with the techniques of functional scintigraphy and single photon emission computed tomography （SPECT）, it becomes possible to functionally simulate the extension of hepatic resection and predict to some extent postoperative outcomes related to liver function. It is still a new professional field internationally, and almost absent domestically. surgery and help determining the It could be an important tool for surgical procedures. We have here, field , written a review of ASGPR scintigraphy. quantificational evaluation of the risk of liver with some of our research experiences in this field , written a review of ASGPR scintigraphy.
出处
《基础医学与临床》
CSCD
北大核心
2006年第5期538-541,共4页
Basic and Clinical Medicine
