微小组合乳房假体与传统单一假体包膜挛缩的比较研究

Lower capsular contracture of miniprostheses as compared with the conventional silicone implant

目的了解微小组合硅凝胶乳房假体置入肌层下的包膜挛缩特点,并与传统单一大假体进行比较。方法30只大白兔,每只大白兔背部两侧肌层下分别置入10ml微小硅凝胶假体4个、40ml传统硅凝胶乳房大假体1个。3个月时进行包膜挛缩Baker评级,压缩实验,包膜切开后裂开宽度,包膜厚度的比较,取包膜样本切片进行HE染色,镜下观察比较包膜特点。结果微小组合假体Baker评级、包膜裂开最大宽度、包膜厚度均明显低于大假体组(P<0·01)。假体压缩率明显高于大假体组(P<0·01)。微小组合假体形成的包膜较传统假体包膜凸凹不平,胶原排列较屈曲且膜薄。结论微小组合假体较传统假体有更低程度的包膜挛缩,有一定的隆乳术应用前景。

Objective To determine if miniprostheses would form a capsule of significantly different biophysical, biochemical and histologic properties than the conventional silicone implant. Methods Four miniprostheses （experimental group） and one big silicone implants （control lgroup） were seperatelly implanted beneath the panniculus carnosus muscle of 30 rabbits. After 3 months, measures related to contracture and capsular histology were performed on anesthetized animals. Results Baker ranking, capsular incision width and capsular thickness of the control groups were evidently higher than that of experimental groups （ P 〈 0.01 ）. Implant compression of the control groups was evidently lower than that of the experimental group. Histology revealed a thinner, more flexed capsule around the miniprostheses as compared with big silicone implants. Conclusions The miniprostheses form a looser and thinner capsule than the conventional silicone implant.