尼卡地平联用拉贝洛尔在高血压伴窦速患者急诊手术中的初步应用

The Effect of the Combination of Nicaidipine and Labetalol on Patients With Hypertension and Sinus Tachycardia Undergoing Emergency Operation

目的观察重度高血压伴窦性心动过速患者急诊手术时联合应用尼卡地平和拉贝洛尔的疗效.方法重度高血压伴窦性心动过速的急症手术患者34例均于诱导前10 min给予尼卡地平10～15 μg/kg.h和拉贝洛尔1～4 μg/min静滴,观察用药前后、诱导前后、插管时的收缩压（SBP）、舒张压（DBP）、平均动脉压（MBP）及心率（HR）变化.结果给药后5 min,SBP、DBP、MBP和HR出现显著变化（P〈0.05）.诱导后5 min、插管时、插管后5 min、插管后10 min,SBP、DBP、MBP和HR均显著低于给药前（P〈0.05）,与诱导前比差异无显著性.结论在高血压伴窦性心动过速患者急诊手术中,联合应用尼卡地平和拉贝洛尔可以快速、平稳控制血压,降低心率,维持血流动力学稳定.

Objective To observe the curative effect of the combination of nicardipine and labetalol on patients with serious hypertension and sinus tachycardia undergoing emergency operation. Methods 34 patients with serious hypertension and sinus tachycardia who need emergency operation were given nicardipine（ 10 - 15 μg/kg. h） and labetalol（ 1 -4 μg/min） before anesthesia induction, and the change of systolic pressure（SBP）, diastolic pressure （DBP） ,mean arterial pressure（MBP） and heart rate（HR）were observed before and after medication, anesthesia induction and during cannula. Results Significant changes（ P 〈 0.05 ）of SBP, DBP, MBP and HR were observed 5 minutes after injection. The SBP, DBP, MBP and HR of 5 minutes after anesthesia induction, during cannula, 5 minutes after cannula, 10 minutes after cannula significantly decreased than before injection, and there was no significant change compared with before injection. Conclusion The combination of nicaidipine and labetalol on patients with hypertension and sinus tachycardia undergoing emergency operation can control blood pressure steadily, decrease heart rate and maintain the stabilization of hemedynamics.