产后抑郁症患者雌、孕激素及催乳素变化的研究

A study of the changes of estradiol,progestogen and prolactin in patients with postpartum depression

目的:研究产后3d与42d雌二醇(E2)、孕酮(P)、催乳素(PRL)水平变化与产后抑郁症的关系。方法:采用Ed in-burgh(EPDS)抑郁量表评定152例产妇产后抑郁情况,比较产后3d及42d的抑郁症发病率,并对比其产后3d与42d的E2、P、PRL水平的差异。结果:抑郁症产后42d发病率明显低于产后3d(P<0.01);抑郁组产后3d、42d血清E2均低于正常组(P<0.05或P<0.01),产后42d血清P水平高于正常组(P<0.05);抑郁组产后3d、42d血清E2水平与EPDS量表分呈负相关性,产后42d血清P水平与EPDS量表分呈正相关性;PRL变化不恒定(P>0.05)。结论:产后体内雌孕激素变化可能是产后抑郁症的诱因之一。

Objective： To study the changes of estradiol （E2）, progestogen （P）and prolactin （PRL）, and their relationships with postpartum depression. Methods： 152 parturiens were evaluated by the Edingburgh postnatal depression scale （EPDS） on the 3d and 42th days after labor and the incidence rates were determined,meanwhile the serum levels of estradiot, progestogen and prolactin were detected by radioimmunoassay. Results： The incidence rate of postpartum depression on the 42th day was significantly lower than that on the 3d day（P.〈0. 01）; the serum level of Ezin patients with postpartum depression was lower than that of normal parturiens on both 3th and 42th days （ P〈0. 05 or P〈0. 01）,which was negatively related to the scores of EPDS, and the serum level of P in patients with postpartum depression was higher than that in normal parturiens on the 42th day （P〈0. 05）, which was positively related to the scores of EPDS,while there was no significant difference in the serum level of PRL in all subjects. Conclusion： The changes of estradiol and progestogen may play a rote in postpartum depression.