前列腺素E_2与维生素E、雌二醇联合应用抗动脉粥样硬化的实验研究

EXPERIMENTAL STUDY ON ANTIATHEROSCLEROTIC TREATMENT BY PGE_2 COMBINED WITH VITAMIN E AND ESTRADIOL

应用同位素技术、血清过氧化脂质（ＬＰＯ）、血小板聚集比、血脂测定及形态学和超微结构等多种检测指标，观察了大剂量前列腺素Ｅ２（ＰＧＥ２）分别与维生素Ｅ和雌二醇联合应用对实验性动脉粥样硬化的（ＡＳ）影响，结果多种指标显示联合用药比单独用ＰＧＥ２具有更明显的抑制ＡＳ协同作用。文中对其作用机理进行了讨论。

The effects of PGE2 combined with vitamin E and with estradiol on experimental atherosclerosis were studied by means of morphological,ultrastructural,autoradiographic and several functional techniques.The results showed that two combined treatment groups had more coordinative inhibition on aortic and coronary atherosclerotic lesions than that of single dose of PGE2.It was revealed that the coordinative mechanism might be closely related to the synergistic inhibition of above metioned drugs on endothelial permeability,platelet aggregation,smooth muscle cell proliferation and lipid peroxidation.