肝纤克对大鼠肝纤维化的影响

The Effects of the Mixture of GQK on Hepatocirrhosis in Experimental Rats

目的 研究肝纤克（GQK）时实验性大鼠肝纤维化的保护作用。方法 以四氯化碳制备大鼠慢性肝纤维化模型，观察血清ALT，ALB，GLB含量；用放免法检测血清PC-Ⅲ，HA，LN，HYP含量以及肝组织中HYP含量，并计算出肝组织胶原含量。结果 ①GQK（0．5～1．0g／kg·po）使肝纤维化大鼠血清ALT明显下降（n=10，P〈0．01），ALB含量明显回升，A／G比值升高（n=10，P〈0．05），提示GQK时肝纤维化大鼠的肝功能有保护伤作用；②GQK使肝纤维化大鼠血清HYP明显下降（n=10，P〈0．05），肝组织HYP含量以及肝组织胶原含量也明显下降（n=10，P〈0．01）；③GQK使肝纤维化大鼠血清PC-Ⅲ，HA及LN均明显下降（n=10，P〈0．01），提示GQK结四氧化碳致大鼠肝纤维化的过程有抑制作用。结论 GQK对实验性大鼠肝纤维化有明显的保护作用。

Objective To evaluate the protective action of the traditional Chinese mixture of Gan Qian Ke（GQK） on hepatocirrho- sis in experimental rats. Methods Hepatocirrhosis were induced by Tetrachloromathance （0. 1% - 10 ml/kg, ip）in rats. The levels of serum ALT ,ALB and GLB were examined by biochemistry. The levels of serum PC - Ⅲ ,HA、LA,HYP were also measured by radioimmunoassay. Results ①GQK（0.5 ～ 1.0 g/kg · po）could decerease the level of serum ALT（ n = 10, P 〈 0. 01 ）and increase the level of serum ALB of hepatocirrhosis rats, the A/G ration on the liver funtion ;②GQK could reduce the level of serum HYP（ n = 10, P 〈 0.05 ） and hepatic tissue HYP （ n = 10, P 〈 0.01 ） ; ③The serum PC - Ⅲ, HA and LN of hepatocirrhosis rats were also lowered by GQK（ n = 10, P 〈 0. 01 ） respectively. It indicates that GQK might inhibit the progress of hepatocirrhosis by Tetrachloromathane in rats. Conclusion These results suggested that GQK might possess the protective action on hepatoirrhosis in exeperimental rats.