摘要
用卡铂和足叶乙甙联合化疗方案(CE方案)治疗50例晚期非小细胞肺癌,并观察其疗效和毒副作用。结果:部分缓解10例,有效率20.0%,缓解期4.25月。中位生存期7月;1、2、3年生存率分别为36%、8.6%、3.6%。鳞癌9例、腺癌32例,有效率分别为44.4%和15.6%,中位生存期分别为9月和7月,Ⅲ期24例,Ⅳ期26例,有效率分别为25.0%和15.4%,中位生存期分别为8月和7.5月。部分缓解、稳定及进展的中位生存期分别为11月、8月和7月。主要毒副反应为骨髓抑制、消化道反应,肝肾功能轻度受影响。
Thc clinical effect and sid c cffcct of carboplatin and ctoposidc(CE regimen)on50 cases of non-small cell lung cancer were observed.The rcsuIts showcd that the overallresponse rate was 20.0%, mcdiati duration of response was 4.25 months,mcdian survitral was 7months,and with actuarial survival rate of 36%,8.6%and 3.6%at year 1,2 and 3respcctively. 9 cases were squamous cell carci noma,3 2 were adenoCarcinoma. The responserates were 44.4%and l5.6%, median survival was 9 months and 7 months, respectively.Theresponse rates in stage Ⅲ(24)and stage Ⅳ(26)were 25.O%and l5.4%, median survival was8 months and 7.5 months, resectively. Med lan survival in patients of PR,S and P was 11months, 8 months and 7 months,respectively. The sidc effects of CE regimen were leukopenia,gastrointestinal uncomfortable.and mild hepatic function changes;
出处
《肿瘤研究与临床》
CAS
1996年第2期92-94,共3页
Cancer Research and Clinic
关键词
肺肿瘤
非小细胞肺癌
卡铂
足叶乙甙
药物疗法
Advanced non-small ceII Iung cancer Carboplatin Etoposidc Chemotherapy