脑梗塞病人脑脊液及血浆vWF含量的研究

The Study of the Contents of vWF in CerebrospJnal Fluid and Plasma of Suffering From Cerebral Inferction

血浆中 vWF 与脑血管疾病的关系曾有过报道,而脑脊液中是否含有 vWF 以及它与缺血性脑血管疾病的关系,尚未见这方面的研究。我们应用双抗夹心酶联免疫吸附试验(ELISA)法测定了30例脑梗塞急性期病人脑脊液和血浆中 vWF 的含量,结果表明:病人组脑脊液和血浆中vWF 的含量较对照组显著升高(P<0.001)。说明 vWF 不仅是高凝状态的指标之一.而且是血管内皮细胞功能受损的分子标记物。脑脊液中 vWF

The relationship between the vWF in piasma anti cerebral vascular disease had been reproted,while little is known the changes of vWF in cerebrospinal fluid (CSF)when cerebral infarc- tion.With ELISA method we measured vWF in CSF grad plasma of 30 cases suffering from cerebral infarction.The results showed that during the acute period of cerebral infarction the contents of vWF in CSF and plasma were higher significantly than that of the control group(P<0.001).The resuits suggested that not only vWF is one of the parameters,but also is the molecular marker of damage in the endotheliocyte.The vWF in the CSF is the specific parameter of the damage at endothelicyte of cerebral vessels.