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胰岛素与血小板L-精氨酸/一氧化氮系统 被引量：1

Insulin and L-Arginine /NO Pathway in Platelets
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摘要 胰岛素抵抗在2型糖尿病和代谢综合征中占有核心地位。大多数研究认为胰岛素有直接抑制血小板活化的作用,且主要是通过L-精氨酸/一氧化氮系统增加血小板内cGMP水平来抑制血小板聚集的。目前已经发现血小板也会发生胰岛素抵抗。而且血小板发生胰岛素抵抗可能存在多个环节。本文主要探讨胰岛素和血小板L-Arg/NO系统间的关系及胰岛素抵抗时血小板L-Arg/NO系统的改变。 Insulin resistance is crucial in the pathology of type 2 diabetes mellitus and metabolism syndrome. The insulin - induced plate.let anti - aggregating effect is attributed to a nitric oxide （ NO ） - mediated increase of cyclic guanosine monophosphate （cGMP）. But this effect will be impaired in diabetes mellitus patients and insulin resistance will present to platelets. Our aim is to review how insulin affect L- Argi- nine/nitric oxide pathway in Platelcts and the changes of L- Argimine/nitric oxide pathway in Platelets when platelets resist to insulin.
作者 毛源杰 齐永芬
机构地区 北京大学第一医院心血管病研究所
出处 《现代生物医学进展》 CAS 2006年第3期36-38,42,共4页 Progress in Modern Biomedicine
关键词 血小板 胰岛素 L-精氨酸/一氧化氮系统 胰岛素抵抗 platelet insulin L- Arginine/nitric oxide pathway insulin resistance
分类号 Q578 [生物学—生物化学] Q592.1 [生物学—生物化学]
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参考文献30

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二级参考文献9

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共引文献7

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  • 2Gouri Shanker,Jimmy L. Kontos,Delrae M. Eckman,Deborah Wesley-Farrington,David C. Sane. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts[J] 2006,Journal of Thrombosis and Thrombolysis(3):213～220

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现代生物医学进展
2006年 第3期

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