胃－食管返流的临床研究

THE CLINICAL STUDY ON GASTROESOPHAGEAL REFLUX

作者采用国产ＳＧＹ－３型多功能消化道检测仪对８０例具有胃－食管返流（ＧＥＲ）症状患者进行了食管测压研究。患者分为两组：Ａ组３３例，内镜及活检食管粘膜正常；Ｂ组４７例，内镜及活检均证实有食管炎。正常对照组６０例。食管炎患者给予吗丁啉口服。结果显示：（１）Ａ、Ｂ两组患者食管下括约肌压力（ＬＥＳＰ）、胃－食管屏障压、食管下括约肌（ＬＥＳ）松驰率明显降低，ＬＥＳ松驰时间明显延长、ＬＥＳ长度（ＬＥＳＬ）短于正常，食管蠕动波压力明显降低（Ｐ＜０．０５，０．０１）；（２）Ｂ组ＬＥＳＰ、胃－食管屏障压明显低于Ａ组（Ｐ＜０．０５），这与临床上ＧＥＲ症状发生率Ｂ组高于Ａ组相符合；（３）吗丁啉使Ｂ组ＬＥＳＰ胃－食屏障压分别升高０．３９±０．４８和０．３４±０．４９ｋＰａ，但对食管蠕动无影响。因而，应用吗丁啉治疗ＬＥＳ功能低下引起的ＧＥＲ是合理、有效的。

Esophageal motility have been investigated in 80 patients with symtomatic gastroesophageal reflux(GER) by SGY-3 digestive tract motility measuring instrument made in China.Patients were subdivided into two groups based on endoscopy and biopsy. A group, normal endoscopy and biopsy (n=33).B group,esophagitis(n=47). The results were compared with 60 healthy subjects. The patients with esophagitis were given oral administration of domperidore. Measured parameters before and after taking medicine were compared. In conclusion:(1) In all of patients,the lower esophageal sphincter pressuure(LESP),the gastroesophageal barlier pressure (GEBP),the rate of LES relaxation,the amplilude of esophageal peristalsis and the length of LES(LESL) were significanlty reduced and the time of LES relaxation extend (P<0. 05,0.01).(2)The LESP and the GEBP were lower in B group than in A group (P<0.05). These accorded with the fact that the symtom of GER wre more severe in B group than in A group.(3)After taking domperidone, LESP and GEBP increased by 0.39±0. 48 and 0.34±0.49Kpa respectively in Bgroup(P<0.05,0. 01) and the amplilude of esophageal peristalsis,no change.