国产帕罗西汀与多塞平治疗焦虑症对照研究

A control study of paroxetine and Doxepine in the treatment of general anxiety disorder

目的:评价国产帕罗西汀(乐友)治疗广泛性焦虑症的临床疗效和安全性。方法:60例广泛性焦虑症病人随机分为两组,分别给予乐友或多塞平治疗6周。采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)评定疗效,用副反应量表(TESS)评定不良反应。结果:乐友组有效率为83.33%,与多塞平组比较差异无显著性;不良反应少而轻,安全性好。结论:乐友治疗广泛性焦虑症是有效的。

Objective：To evaluate the efficacy and safety of paroxetine in the treatment of general anxiety disorder（GAD）. Methods ： 60 patients with GAD were randomly assigned into the treatment groups of paroxetine or Doxepine for 6 weeks. HAMA . CGI were adopted to evaluate the therapeutic response. TESS were used to assess the side effects. Results： 83.33 % of patients responded to paroxetine. No significant difference was found between the groups. The adverse effects of paroxetine were less and mild. Conclusions： paroxetine is effectiver in treating GAD.