摘要
目的:研究川芎嗪脂质体的制剂。方法:以乙醚注入法制备川芎嗪脂质体,以正交设计优化制备工艺,并对其包封率进行计算。结果:最佳工艺条件为药物∶磷脂为1∶10,PBS缓冲液pH为7.0,胆固醇∶磷脂为1∶3,乙醚∶PBS缓冲液为1∶6。结论:川芎嗪脂质体制剂包封率高、稳定性好,适合开发应用。
Objective: To study the preparation of the ligustrazine hydrochloride liposome. Methods: The liposomes were prepared by ether injection method and the technology was selected by orthogonal design. The encapsulated ratio was studied. Results: The ideal combination of preparation is drug : lipid = 1 : 10, pH values of PBS is 7.0, cholestrol : lipid = 1 : 3, ether : PBS= 1 : 6. Conclusion:The encapsulated ratio and the character of the preparation of ligustrazine hydrochloride liposome is suit to development and application.
出处
《山东中医药大学学报》
2006年第3期255-257,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
山东省中医管理局资助项目(2003-40号)
关键词
盐酸川芎嗪
脂质体
正交设计
ligustrazine hydrochloride
liposome
orthogonal design