摘要
目的:探讨Flt4在甲状腺乳头状癌中的表达及其与淋巴道转移的关系。方法:用免疫组化SP法检测44例甲状腺乳头状癌及其癌旁组织中Flt4表达情况。结果:44例甲状腺乳头状癌组织Flt4阳性27例,阳性率为61．36％,阳性表达率在淋巴道转移组显著高于无转移组(P<0．05),癌组织中Flt4阳性微脉管数在淋巴道转移组显著高于无转移组(P<0．05);癌旁甲状腺组织Flt4呈阴性表达。结论:Flt4参与了甲状腺乳头状癌淋巴道转移过程,测定肿瘤组织Flt4表达及Flt4阳性微脉管数有助于预测甲状腺乳头状癌是否伴淋巴道转移。
Objecetive： To study the relationship between expression of Flt4 and lymph node metastasis of thyroid papillary carcinoma. Methods： The expression of Flt4 was examined by SP immunohistoehemieal technique in 44 cases of thyroid papillary carcinoma and their adjacent tissues. Results： The positive rate of Flt4 was 61.36% in thyroid papillary carcinoma. The positive rate of Flt4 and the numbers of Flt4 positive microvessels in the eases with lymph node metastasis were significantly higher than those with localized diseased alone （P 〈 0. 05）. While the adjacent tissues of thyroid papillary carcinomas were negative to Flt4. Conclusion： Flt4 maybe play and important role in the development and lymph node metastasis of thyroid papillary carcinoma. It may be a useful marker to predict the thyroid papillary carcinoma with lymph node metastasis.
出处
《四川肿瘤防治》
2006年第2期81-82,共2页
Sichuan Journal of Cancer Control
基金
广西省科技厅自然基金资助课题(No.0542062)。
