摘要
为检测绿茶口含片的食用安全性,通过急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)、30d喂养试验进行毒理学研究。结果:雌雄两性大、小鼠经口MTD均大于20.0g/kg体重,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性,显示无致突变性。30d喂养试验(5.00g/kg体重)未见动物出现中毒症状。结论:绿茶口含片急性毒性分级属无毒级、无遗传毒性,试验中最大无损害作用剂量大于5g/kg体重,食用安全性高。
To evaluate the edible safety of green tea buccal tablets(GTBT), tests included acute toxicity test, Aames test, Micronucleus test, Sperm shape abnormality test and thirty days feeding test were performed. Results shows that: The oral maximum tolerated dose(MTD) was higher than 20.0 g / kg.bw both in male or female mice and rats. Ames test, Micronucleus test and Sperm shape abnormality test were positive. No significant toxicity was detected in thirty days feeding test. Conclusion: Green tea buccal tablets has no acute toxicity, no genotoxicity, high in edible safety.
出处
《茶叶科学》
CAS
CSCD
北大核心
2006年第2期122-127,共6页
Journal of Tea Science
关键词
绿茶口含片
急性毒性
最大耐受量
遗传毒性
安全性
green tea buccal tablets, acute toxicity, maximum tolerated dose, genotoxicity, edible safety