妊娠期糖耐量异常对新生儿血糖水平影响的前瞻性对照研究

Prospective control study on the effect of abnormal gestational glucose metabolism on neonatal glucose value

目的 通过对妊娠期糖耐量异常和妊娠期血糖正常产妇所分娩的新生儿出生后24h内5个时点血糖水平的动态监测对比，分析妊娠期糖尿病对新生儿血糖水平的影响。进一步完善妊娠期糖尿病的系统管理方法，避免新生儿低血糖的发生。方法 选择我院产科2003年6月～2004年6月住院孕妇所分娩的新生儿，妊娠糖尿病孕妇所分娩的新生儿66例，其中妊娠期糖尿病（GDM）47例，妊娠期糖耐量异常（GIGT）的19例与同期正常孕妇所分娩的新生儿66例比较。结果 两组新生儿血糖值24h内5个时点的比较，差异无统计学意义。新生儿体重比较差异无显著性意义。结论 观察分析新生儿低血糖的发生率并能及时治疗，纠正低血糖，减少合并症的发生，反映了系统管理妊娠期糖尿病及糖耐量受损的治疗效果。对临床治疗和护理有指导意义。

Objective To analyze the influences of gestation diabetes mellitus （GDM） on neonatal blood glucose level. Methods Neonates were selected from those delivered in the obstetrical department of first hospital of Peking university from June 2003 to June 2004, and were divided into two groups, testing group included neonates with maternal abnormal glucose metabolism（66 cases） consisting of 47 with maternal GDM and 19 with maternal GIGT; another 66 newborns born from normal pregnant women were as control. Neonatal blood glucose value was measured at 5 different times within 24 hours after being delivered. Results No significant difference was shown neither in all neonatal blood glucose levels in all 5 points between the two groups nor in neonatal birth weight. Conclusions Neonatal blood glucose level monitoring allows earlier management of hypoglycemia, thus reduces other induced complications. On the other hand, the incidence of neonatal hypoglycemia reflects the effect of GDM and GiGT management,and is valuable for clinical practice, nursing and improve the quality of patient care.