柠檬酸酐的合成与表征

Synthesis and Characterization of Citric Acid Anhydride

以柠檬酸和乙酸酐为原料,乙酸为溶剂合成柠檬酸酐。用正交实验考察反应时间、反应温度、溶剂用量和物料配比对柠檬酸酐产率的影响。得出的最优化条件为:反应时间18 h,反应温度37℃,摩尔比n(柠檬酸)∶n(乙酸酐)∶n(乙酸)为1∶1.8∶2,产率为84%。产品分子量为174,红外光谱证明产品为五元环状酸酐。

Citric acid anhydride was synthesized by citric acid （CA） and acetic anhydride（AA） with acetic acid as solvent. The effects of reaction time, reaction temperature, the dosage of solvent and molar ratio of raw materials on yields were studied through orthogonal test. The optimum condition was： reaction time 18h, reaction temperature 37 ℃, molar ratio of n（CA） ： n（AA） ： n（acetic acid） 1：1.8：2, the yield 84%. Structure of citric acid anhydride was spectrum and its molecular 174. proved to be five-number cyclo - anhydride by IR