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紫杉醇类治疗12例转移性乳腺癌大量恶性胸腹腔积液3年疗效观察 被引量:4

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摘要 目的 探讨紫杉醇类药物对转移性乳腺癌所致大量胸、腹腔积液的疗效和不良反应。方法 紫杉醇类药物(紫杉醇175mg/m^2或多西紫杉醇25mg/m^2)静脉滴注第1天,每21天为1周期,治疗6个周期评价疗效,随访1~3年。结果 12例胸腹腔积液中,完全缓解11例,无效1例,有效率91.67%,1年生存率75.00%.3年生存率33.33%。主要不良反应:脱发及骨髓抑制。结论 紫杉醇类药物是治疗转移性乳腺癌恶性胸、腹腔积液有效手段,耐受性好。
出处 《重庆医学》 CAS CSCD 2006年第10期944-945,共2页 Chongqing medicine
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  • 1Sledge GW,Neuberg D,Bernardo P.Phase III trial of doxorubicin,paclitaxel,and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer:an intergroup trial (E1193) [J].J Clin Oncol,2003,21(4):588
  • 2Gebbia V,Blasi L,Borsellino N,et al.Paclitaxel and epidoxorubicin or doxorubicin versus cyclophosphamide and epidoxorubicin as first-line chemotherapy for metastatic breast carcinoma:a randomised phase II study[J].Anticancer Res,2003,23(1B):765
  • 3Horwitz SB,Cohen D,Rao S,et al.Taxel:mechanisms of action and resistance[J].J Nail Cancer Inst,1993,15:15
  • 4Friedrichs K,Holzel F,Janicke F.Combination of taxanes and anthracyclines in first-line chemotherapy of metastatic breast cancer:an interim report[J].Eur J Cancer,2002,38(13):1730
  • 5Hsu C,Huang CS,Chao TY,et al.Phase II trial combining paclitaxel with 24-hour infusion cisplatin for chemotherapy-naive patients with locally advanced or metastatic breast carcinoma[J].Cancer,2002,95(10):2044
  • 6Zimatore M,Danova M,Vassallo E,et al.Weekly taxanes in metastatic breast cancer (review) [J].Oncol Rep,2002,9(5):1047
  • 7Markman M, Reichman B, Hakes T, et al. Intraperitoneal chemotherapy in the management of ovarian cancer. Cancer, 1993, 71(Suppl 4): 1565-1570.
  • 8Zimm S, Cleary SM, Lucas WE, et al. Phase I/pharmacokinetic study of intraperitoneal cisplatin and etoposide. Cancer Res, 1987, 47: 1712-1716.
  • 9贾博琦.现代临床实用药物手册(第2版)[M].北京:北京科技大学出版社,2002.732.
  • 10Katano M, Torisu M. New approach to management of malignant ascites with a streptococcal preparation, OK-432. Ⅱ. Intraperitoneal inflammatory cell-mediated tumor cell destruction.Surgery, 1983,93:365-373.

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