正常人视网膜厚度定量测量的研究

Quantitative In Vivo Retinal Thickness Measurements in Healthy Subjects

目的:测量正常人后极部视网膜的厚度,以建立正常人后极部黄斑周围区域视网膜的厚度图,旨在为一些与视网膜厚度改变有关的眼部疾病的诊断提供依据。方法:用视网膜厚度分析仪(Retinal Thickness Analyzer,RTA),对61例(61只眼)正常人行后极部黄斑周围区域6mm×6mm大小范围视网膜厚度的定量测量,所取图像经计算机处理后,得到上述部位视网膜的数据及二维、三维图像。结果:正常人后极部视网膜厚度图呈马蹄形,上下对称,黄斑鼻侧视网膜较颞侧厚10.45%,与后极部解剖相吻合。正常人后极部平均视网膜厚度为(177.95±26.19)μm,正常男性为(177.22±20.57)μm,正常女性为(178.67±19.61)μm,性别及年龄之间差异无统计学意义(P>0.05)。结论:用RTA进行的视网膜厚度分析可快速提供后极部视网膜厚度图,能敏感地检测病理性视网膜增厚或变薄,从而为一些眼部疾病的诊断提供了依据。

Objective： An objective, quantitative and sensitive method to map the retinal thickness at the posterior pole is needed to diagnose more effectively the diseases causing alterations in thickness. We studied the normal, thickness at the posterior pole. Methods： A new instrument, the retinal thickness analyzer（RTA） was capable of covering the central 20°of the fundus and generating a detailed map of the retinal thickness. The measurements were performed in 61 normal subjects; the data were analyzed with SAS software package. Result： The thickness maps of normal subjects expressed a horseshoe shape with symmetry between above and below the fovea which matched the posterior pole anatomy, and the macular nasal retina is 10.45% thicker than its temporal side. The mean retinal thickness of posterior pole was（ 177.95±26. 19）μm in normal subjects man, （177.22±20. 57） μm; woman, （ 178.67±19.61 ） μm. No significant difference was obtained in age and gender in the retinal thickness of posterior pole either in each of the 9 detecting point of posterior pole （ P 〉 0. 05 ）. Conclusion： Rapid scanning thickness analysis with the RTA provides a detailed map of the retinal thickness. The method may provide a sensitive detection of pathologic thickening or thinning of the retina and prove valuable in detecting retinal thickness alteration in ocular diseases.