多种蓝色混合染色在乳腺癌前哨淋巴结活检中的临床应用

Study of Sentinel Lymph node Biopsy with the Mixed Blue Injected in Patients with Breast Cancer

目的:探讨多种蓝色染料混合染色鉴别前哨淋巴结(SLN)的成功率及预测乳腺癌腋窝淋巴结转移的准确性;为SLND提供一种较佳的示踪染料。方法:从2005年1月至2006年1月我科收治的乳腺癌病例中选取19例实施了前哨淋巴结活检(snb),分美蓝组(1%美蓝3m l)和复合染色组(1%专利蓝,1%异硫蓝,1%美蓝各1m l混合)两组,于术中在乳腺肿块周围腺体内注射,以鉴别定位SLN,全部病例都实施了腋淋巴结清扫术。结果:SLN鉴别的成功率美蓝组和复合染色组分别为77.8%(7/9)和90%(9/10)(P<0.01);预测腋淋巴结转移状态准确性分别为88.9%(7/8)和100%(10/10)(P>0.05)。结论:与美蓝比较,该混合染料是较理想的乳腺癌SNB的生物活性染料示踪剂。

Objective： To study the identification rate of sentinel lymph node （ SLN ） in patients with breast cancer and the accuracy in predicting axillary lymph node （ ALN）, using the mixed dyestuff （ methylence blue, patent blue violet, isosulfan blue ）. The purpose of this research is to find one better tracer material using in clinic from the breast cancer. Method： From January 2005 to January,2006,19 patients with breast cancer were selected for this study. Of them,9 patients were injected with 1% methylence blue and 10 patients were injected with the mixed blue materials. All 19 patients underwent the axiltary lymph node dissection. Result： In methylence blue ground and the mixed ground,the identification rate were 77.8% （7/9） and 90% （9/10） ; the accuracy rate to predict axillary lymph node were 88.9% （7/8） ,100% （10/10） respectiveely. Cone.luSh： Compared with methylence blue, this mixed blue is the more ideal blue dye in identification of SNB.