摘要
目的探讨急性冠状动脉综合征(ACS)辛伐他汀与动脉粥样斑块稳定的可能机制。方法选择稳定型心绞痛(SAP)患者30例作为对照。随机将ACS患者分成辛伐他汀治疗组(30例)及常规治疗组(30例),比较各组患者血清MMP-1、MMP-3水平变化。结果SAP、ACS、健康对照三组之间MMP-1、MMP-3水平比较差异有统计学意义,辛伐他汀治疗组与常规治疗组治疗后血清MMP-1、MMP-3水平相比差异有统计学意义。结论辛伐他汀可降低ACS患者血清MMP-1、MMP-3水平,从而起到稳定动脉粥样硬化斑块的作用。
Objective To observe the effect simvastain of serum levels of matrix metalloprotease-9 （ MMP- 1, MMP-3） in patients with acute coronary syndromes （ACS）. Methods 90 patients with coronary heart disease were studied. Among them there were 30 patietns with stable angina pectofis （SAP） and 60 patients with ACS, At the same time,30 cases of age matehed healthy individuals were selected as a control ,54 patients with ACS were randomly divided into 2 groups： amivastatin treatment group and regular treatment group. The serum level of MMP-1 and MMP-3 were compared among all groups. Results There was a significant difference in serum level of MMP-1 and MMP-3 among SAP group,ACS group and control group.The serum level of MMP-1 and MMP-3 were different between amivastatin treatment group and regular treatment group after treatment. Conclusions Plaque disruption may be related to the increased serum level of MMP-1 and MMP-3.Simvastatin can decrease serum level of MMP-1 and MMP-3 in patients with ACS. Amivastatin may have a beneficial effect on steadying the plaque.
出处
《西南军医》
2006年第3期8-10,共3页
Journal of Military Surgeon in Southwest China
