慢性肺心病急性期血浆α颗粒膜蛋白、凝血谱测定的临床价值

The Clinical Value of α-granule Membrane Protein and the Coagulation to the Chronic Pulmonary Heart Disease

目的探讨α颗粒膜蛋白(GMP140)、纤维蛋白原(Fib)、凝血酶原时间(PT)及其活动度(PTA)、部分凝血活酶时间(APTT)、凝血酶时间(TT)对慢性肺心病急性期的诊断价值。方法采集52例慢性肺心病急性期患者、对照组36例静脉血,采用ELISA法测定血浆内GMP140、PTA;SYSMEX CA-1500型凝血仪测定凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib),并与对照组进行比较。结果慢性肺心病急性期组血浆GMP140、Fib、FPA明显高于正常对照组,而PT明显短于正常对照组。结论测定血浆GMP140、Fib、PT、APTT、TT及APTT对慢性肺心病急性期病程发展和血栓的形成有重要的临床意义。

Objective To discuss the value of the α-granule membrane protein （G140）, the Fib, the PT, the APTT, the TT and the FPA to the chronic pulmonary heart disease. Methods The serums of 52 eases in chronic pulmonary heart disease and in 36 cases in the normal group were taken, the GMP, FPA were detected with ELISA while the PT, APTT, Fib and TT were detected with the SYSMEX CA-1500. Results The results of the GMP140, Fib, and FPA in the chronic pulmonary heart disease group were much higher than those in the normal group, and its PT was lower than that in the normal group. Conclusions The detection of the GMP140, Fib, PT, APTT, TT, and FPA is of clinical value to the chronic pulmonary heart disease.