E-cadherin和CD44_(V6)蛋白在大肠癌患者中表达的临床意义

Expression and significance of E-cadherin and CD44_(V6) in colorectal carcinoma.

目的探讨E-cadherin和CD44V6在大肠癌患者大肠黏膜组织中的表达及其意义。方法应用免疫组织化学标记链霉菌抗生物素蛋白过氧化物酶方法,对52例大肠癌患者癌组织中E-cadherin和CD44V6蛋白的表达水平进行了检测。结果E-cadherin和CD44V6在大肠癌组织中的表达阳性率分别为59.6%和57.7%,E-cadherin和CD44V6的异常表达与大肠癌的浸润深度、淋巴结转移、Dukes分期显著相关(P<0.05)。E-cadherin蛋白高表达者3年生存率为62.3%,而低表达者为37.7%CD44V6蛋白表达阳性者5年生存率为36.7%,而阴性者为63.3%,阳性表达者与阴性表达者生存率差别有显著性意义(P<0.05)。E-cadherin与CD44V6蛋白的表达阳性率呈负相关(P<0.05)。结论E-cadherin和CD44V6与大肠癌的进展和淋巴结转移有关,可作为预测肿瘤预后的指标。

Objective To investigate the expression and significance of E - cadherin （ E - cad）, CD44v6in colorectal carcinoma. Methods E - cad and CD44v6 were detected by streptavidin - biotin immunohistochemical methods in 52 cases of colorectal cancer tissue. Results The high expression rates of E - cad were 59. 6% and CD44v6 were 43. 8% in eolorectal carcinoma tissue. Significant correlation existed among the abnormal expression of E -cad and CD44v6, the depth of tumor invasion, lymphnodc metastasis, and Dukes stages（ P 〈 0.05 ）. Furlhennore, the abnorreal expression of CD44v6 was closely associated with the grade of differentiation（ P 〈 0.05 ）. There was a positive correlation between the expression of E - cad and CD44v6 ; The 5 ycar＇s survival rate of patients with the high expression of E - cad was 65.6%, those with the low expression was 28.8%, while there was a significavt different with them （ P 〉 0.05 ）. Conclusion The expression of E - cad and CD44v6 were closely associated with metastasis and development of the colorectal carcinoma, Detection of the expression of E - cad and CD44v6 protein in eoloreetal cancer might served as important prognostic predictors.