替拉扎特对大鼠烟雾吸入伤早期肺损害的抑制作用

The inhibitory effects of tirilazad on the early lung damage in rats with smoke inhalation injury.

目的观察替拉扎特对(Tirilazad)大鼠烟雾吸入伤早期肺损害的影响。方法将W istar大鼠随机分成正常对照组、烟雾吸入伤组和替拉扎特治疗组。伤后6 h分别对大鼠肺组织含水量、131I-白蛋白渗出量、超氧化物歧化酶、肿瘤坏死因子-α和磷脂酶-A2活性进行测定。结果替拉扎特治疗组肺组织含水量、131I-白蛋白渗出量、磷脂酶-A2活性和肿瘤坏死因子-α均明显低于吸入伤组(P<0.01),明显高于正常对照组(P<0.05);超氧化物歧化酶增加明显(P<0.01),但仍低于正常对照组(P<0.05)。结论替拉扎特对烟雾吸入伤大鼠早期肺损害具有一定的抑制作用。

Objection To evaluate the effects of tirilazad on the early lung damage in rats with smoke inhalation injury. Methods Wistar rats were randomly divided into 3 groups： normal group （ control group ）, smoke inhalation injury group （ injury group） and smoke inhalation injury plus tirilazad treatment group （ treatment group）. Lung water content （ LWC ）, exudation of 131I - labelled albumin （ 131I - BSA ）, TNF - α, superoxide dismutase（ SOD）, and phospholipaseA2（ PLA2 ）activity were measured 6 hours after smoke inhalation injury. Results In treatment group, LWC, 131I- BSA, TNF- α and PLA2 activity were significantly decreased （ P 〈0.01 ） as compared with injury group, but significantly higher than that in control group （ P 〈 0.05 ）. In treatment group, SOD was significantly increased , but still significantly lower than that in control group （ P 〈 0.05 ）. Conclusion Tirilazad has some inhibitory effect on the early lung damage in rats with smoke inhalation injury.