两种不同方法用于足月妊娠人工破膜后引产效果的临床观察

Clinical observation of the effect of two different methods on induction of labor of gravidas with full-term pregnancy after artificial rupture of membranes.

目的 探讨米索前列醇用于足月妊娠人工破膜后引产的安全性及效果。方法 将100例孕足月，有引产指征的单胎头住初产妇，年龄23～35岁，宫颈Bishop评分〈7分，进行人工破膜后随机分成两组。试验组60例用米索前死醇25μg阴道给药，2h后重复给药至正式临产；对照组40例静脉滴注催产素。结果 两组引产总有效率无显著差异（P〉0．05），试验组引产时间显著少于对照组（P〈0.01）。结论 阴道放置米索前列醇用于人工破膜后引产能促宫颈成熟及发动子宫收缩，是安全、有效的引产方法。

Objective To investigate the safety and efficacy of intravaginal misoprostol for induction of labor of gravidas with full - term pregnancy after artificial rupture of membranes. Methods One hundred unipara（ age 23 ～ 35 years） with full - term singleton pregnancy, cephalic presentation and cervical Bishop score 〈 7, were randomly assigned to receive intravaginal misoprostol（ n = 60） or intravenous oxytocin（ n = 40）. Rusults There were no significant differences between two groups in the efficacy of induction of labor （ P 〉 0.05 ）, the duration of induction of labor in the misoprostol group was significantly shorter than that in the oxytocin group （ P 〈 0.01 ）. Conclusion Intravaginal misoprostol may be an effective and safe method for induction of labor after artificial, rupture of membranes, misoprostol can accelerate cervical, ripeness and uterus systole.