洛赛克预防重型颅脑损伤后上消化道出血的疗效观察

The Effect of the preventive function of losec to upper gastrointestinal hemorrhage suffered serious craniocerebral injury

目的:观察洛赛克对重型颅脑损伤后上消化道出血的预防作用。方法:对120例重型颅脑损伤的患者随机分为治疗组、对照组,治疗组给予洛赛克40 m g,每日2次静脉注射,对照组给予雷尼替丁150 m g,每日2次静脉注射,两组均在积极治疗原发病的基础上采取上述措施。结果:治疗组发生上消化道出血3例,出血率5.0%,对照组12例,出血率20%,两组比较P<0.05。结论:洛赛克对预防重型颅脑损伤后上消化道出血有显著作用。

Objective：To evaluate the preventive function of losec to upper gastrointestinal hemorrhage of the patients suffered serious craniocerebral injury. Methods：One hundred and twenty patients suffered serious craniocerebral injury are divided into two groups randomly,one group is therapy group,another is contrast group. The patients of therapy group are treated with losec 40mg,mainline twice a day,and the patients of contrast group are treated with ranitidine 150mg,mainline twice a day. Results ：Three patients of therapy group appear upper gastrointestinal hemorrhage ,the hemorrhage ratio is 5.0%. Twelve patients of contrast group appear upper gastrointestinal hemorrhage ,the hemorrhage ratio is 20%. Conclusion：Losec have obvious function to prevent the upper gastrointestinal hemorrhage of patients suffered serious craniocerebral injury.