血清抵抗素与冠状动脉粥样硬化关系研究

Study of the relationship between coronary atherosclerosis and serum resistin

目的:探讨人血清抵抗素水平与冠状动脉粥样硬化(AS)病变程度的关系。方法:根据冠状动脉造影结果和临床表现,将82例临床可疑的冠心病患者进行分组,用酶联免疫法检测血清抵抗素水平,同时监测患者血脂、血压、血糖及体重指数(BMI)等相关指标。结果:(1)动脉粥样硬化病变患者血清抵抗素水平[2.09ng/ml(0.38～5.2ng/ml)]与阴性对照[1.43ng/ml(0.34～4.02)ng/ml]相比差异有显著性,P<0.05。(2)相关分析显示空腹抵抗素水平与腰臀比、体重指数呈显著正相关(分别为r=0.38,P<0.05;r=0.43,P<0.01);而与收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、血糖无相关性(P>0.05)。与高密度脂蛋白胆固醇(HDL-C)呈显著负相关(r=-0.33,P<0.05)。结论:高抵抗素血症可能是动脉粥样硬化发生发展的独立危险因素。

Objective：To explore the relationship between the severity of coronary atherosclerosis and the level of serum resistin. Methods：82 patients with suspected coronary heart disease were dividend into groups according; to coronary arteriography and clinical manifestration. ELISA was used to examine the fasting serum resistin and related parameters such as blood pressure,body mass index （BMI）,fasting blood glucose,lipids and insulin were measured. Results： （1）There was significartt difference in serum resistin between patients with atheroselerosis [2.09 ng/nd （0.38～5.2 ng/ml）] and negative control group [1.43 ng/ml （0.34～4.02 ng/ml）]（P〈0.05）.（2）Related analysis demonstrated that the fasting serum resistin level was positively correlated with WHR and BMI respectively （r=0.38,P〈0.05;r= 0.43,P〈0.01）;but negatively correlated with high-density lipoprotein cholesterol（HDL-C）（r=-0.33,P〈0.01） and not correlated with systolic blood pressure,diastolic blood pressure,total cholesterol triglyceride,low-density lipoprotein cholesterol （LDL-C） and blood glucose. Conclusion：Hyperresistinemia might be the independent risk factor of atherogensis.