早期大剂量纳洛酮治疗急性CO中毒临床观察

Clinical observation of large dose naloxone in acute carbon monoxide poisoning

目的:探讨院前早期应用大剂量纳洛酮治疗急性CO中毒的疗效与安全性。方法:以随机对照设计对145例急性CO中毒昏迷患者进行临床研究,对照组采用常规治疗方案,治疗组在对照组的基础上接受院前早期应用大剂量纳洛酮。观察两组病例在治疗期间的Glascow评分变化、平均意识觉醒时间以及发病2个月时迟发性脑病的发生率的差异。结果:两组病例在治疗期间的Glascow评分、平均意识觉醒时间以及发病2个月时迟发性脑病的发生率等情况的差异显著。结论:院前早期应用大剂量纳洛酮治疗急性CO中毒疗效显著,安全性高。

Objective ：To study the safety and curative effect of large dose naloxone in patients with acute carbon monoxide（CO） poisoning in pre-hospital.Methods： 145 patients with acute CO poisoning were involved in a randomized controlled trial. 69 patients received traditional medication as the control group, 76 patients in the observation group received the scheme that the large dose naloxone was used in pre-hospital on the base of the control group, first,intravenous 2mg naloxone, followed with 12mg naloxone in 5% glucose saline 500ml intravenous last for 24 hours with a micro-pump. The Glascow coma scale before treatment,4 hours, 8 hours, 24 hours, 48 hours and 72 hours after administration, the average analeptic time during the period of having been treated, and the rate of the delayed encephalopathy after carbon monoxide poisoning （DEACMP） at two months after poisoning in the two groups were observed.Results：The Glaseow coma scale, the average analeptic time, and the rate of the DEACMP demonstrated notable differnce between the two groups, and no side-effects.Conclusion： The large dose naloxone used in this manner is better than normal dose in safety and curative effect for saving acute CO poisoning.