儿童呼吸道标本中常见真菌的鉴定及耐药性监测

Identification and monitoring drug resistance of fungus in respiratory tract specimen in children

目的:了解我院儿童呼吸道标本中常见真菌感染的种类及耐药性情况,以便指导临床合理用药。方法:应用YBC鉴定卡对从呼吸道中分离出的665株真菌进行鉴定,用ATB-FUNGS2INT试条进行药物敏感实验。结果:665株真菌中白色念珠菌占57.1%,其次是热带念珠菌、光滑念珠菌、克柔念珠菌,分别为24.8%、16.2%、1.4%。呼吸科、心内科、新生儿科、血液科真菌的检验率分别为:30.1%、13.5%、13.1%、12.1%;665株真菌对氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑总的敏感率分别为93.4%、88.8%、89.6%、75.2%。结论:真菌感染呈上升趋势。主要致病真菌对氟胞嘧啶、两性霉素B、氟康唑的敏感性较高;对伊曲康唑的敏感性较低,应引起临床医生的重视。

Objective：To understand the denomination of fungous infection and drug resistance in respiratory tract specimen at our hospital.Methods：665 fungi from Respiratory Tract specimen were identified by YBC verification card and drug sensitive experiment by ATB-FUNGS 2 INT trial. Results：Candida albicans occupied 57.1% in 665 fungi, Candida tropicalis,slick Monilia and Candida kruse occupied 24.8%, 16.2% and 1.4% respectively.Respiration department,medical department, neonatorum department and blood department were 30.1% ,13.5% ,13.1% and 12.1% respectively.The sensitive rate of 665 fungi to 5FC, AMB,FAC and ITR was 93.4%,88.8%, 89.6% and 75.2% respectively.Conclusion：Fungous infection and drug ：resistance are ascending tendency. Sensitivity of fimgus to 5FC, AMB ,FAC is comparatively high ,sensitivity of fungus to ITR is comparatively low.Must be enhanced attention in the clinic.