1Gitter BD,Boggs LN,May PC,et al.Regulation of cytokine secretion and amyloid precursor protein processing by proinflammatory amyloid beta (A beta)[J].Ann NYA cad Sci,2000,917:154.
2Swatton JE,Sellers LA,Faull RL,et al.Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brbrain[J].Eur J Neurosci,2004,19(10):2711.
4Sprks DL,Kuo YM,Roher A,et al.Alteration of Alzheimer's disease in the cholesterol-fed rabbit,including vascular inflammation[J].Preliminary observations[J].Ann NY Acad Sci,2000,903:335.
5Refolo LM,Malester B,LaFrancois J,et al.Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model[J].Neurobiol dis2000,7(4):321.
9Vassar R,Bennett BD,Babu-Khan S,et al.beta-secretsse cleavage of Alzheimer's amyloid precursor protein by the trans2 Membrane aspartic protease BACE[J].Science,1999,286:735.
3Griffin WS, Sheng JG, Royston MC, et al. Glial-neuronal interactions in Alzheimer's disease: the potential role of a "cytokine cycle"in disease progression. Brain Pathol, 1998, 8: 65-72.
4McGeer EG, McGeer PL. The importance of inflammatory mechanisms in Alzheimer's disease. Exp Gerontol, 1998, 33: 371-378.
5American Psychiatric Association. DSM-IV: diagnostic and statistical manual of mental disorders 4th ed. Washington: American Psychiatric Association, 1994.92-94.
7Rothwell NJ, Luheshi GN. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci, 2000, 23: 618-625.
8Sheng JG, Griffin WS, Royston MC, et al. Distribution of interleukin-1 immunoreactive microglia in cerebral cortical layers: implication for neuritic plaque formation in Alzheimer's disease. Neuropathol Appl Neurobiol, 1998, 24: 278-283.
9Griffin WS, Sheng JG, Roberts GW, et al. IL-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol, 1995, 54: 276-281.
10Alvarez XA, Franco A, Fernandez N, et al. Blood levels of histamine, IL-1 β and TNF-α in patients with mild to moderate Alzheimer's disease. Mol Chem Neuropathol, 1996, 29: 237-252.
