中国北方汉族人寻常型天疱疮与HLA-A、B单倍型的相关性研究

Study on association between HLA-A, B haplotypes and pemphigus vulgaris in Han nation of northeast China

目的:探讨HLA-A、B单倍型与中国东北地区汉族人寻常型天疱疮的相关性。方法:采用标准微量淋巴细胞毒试验方法对寻常型天疱疮患者组及正常对照组进行HLA-I类抗原分型并计算单倍型频率进行比较。结果:与对照组比较,寻常型天疱疮患者组中单倍型HLA-A2、B5,HLA-A2、B13,HLA-A3、B40,HLA-A3、B13,HLA-A3、B16,HLA-A3、B5和HLA-A10、B40的频率明显增高(P<0.05),而单倍型HLA-A2、B46在患者组中未发现。结论:特异单倍型可能是决定寻常型天疱疮发生的重要因素。

Objective： To investigate the relationship between pemphigus vulgaris （PV） and HLA - A, B haplotypes in Han nations of Northeast China. Methods： The HLA - A, B antigens were detected by standard microcytotoxicity test and the frequencies of B haplotypes were compared in patients and controls. Results： Compared with control group, the frequencies of the haplotypes of HLA - A2B5, HLA - A2B13, HLA - A3B40, HLA - A3B13, HLA - A3B16, HLA - A3, B5 and HLA - A10B40 increased significantly in PV group （ P 〈 0.05） compared with control group. The haplotypes of HLA - A2B46 were not found in PV group. Conclusion： The special haplotypes may contribute to genetic susceptibility to PV in northeast Chinese.