^(89)SrCl_2治疗83例多发性骨转移瘤的回顾分析

Retrospective analysis of ^(89)Sr metastron treating 83 cases of multiple osseous metastasis tumor

目的评价89SrCl2对多发性骨转移瘤的疗效和副作用。方法对83例用89SrCl2治疗后的多发性骨转移瘤伴骨痛病例进行回顾性分析,分别从缓解骨痛、骨显像疗效、毒副反应等进行分析。结果83例伴有骨痛的患者经治疗后,31.3%完全缓解,37.3%中度缓解,18.1%轻度缓解,总有效率为86.7%。毒副反应主要为白细胞和血小板一过性降低,且降幅仅达20%左右。结论放射性同位素89Sr内照射治疗多发性骨转移瘤毒副作用低、疗效肯定,值得临床推广应用。

Objective To evaluate the therapeutic effect and side effects of ^89Sr metastron on treating multiple osseous metastasis tumor. Methods The total 83 patients had been treated by intravenously injecting ^89Sr metastron at a dose of 2.22 MBq/kg. Results Among 83 cases, 31.3 % of them got complete remission, 37.3%.moderate remission, and 18. 1% slight remission. The total effective rate was 86.7%. The side effects were mild, and only white blood cells and platelets transiently fell by 20%. Conclusion Internal radiotherapy with ^89Sr metastron is the good alternative in treating multiple osseous metastasis tumor.