儿童眼肌型重症肌无力临床治疗

The Treatment of Ocular Myasthenia Gravis in Children

目的探索儿童眼肌型重症肌无力有效的治疗方法,减少用药量及因药物引起的副作用和并发症。方法对85例儿童眼肌型重症肌无力患者(均有上睑下垂)进行随机分组,分别用吡啶斯的明、强的松及两种药物联合用药治疗,随访3年。结果吡啶斯的明组和强的松组治愈率基本相似,而联合组治愈率明显高于单用吡啶斯的明组或强的松组;并且联合组复发率也明显低于吡啶斯的明组和强的松组。同时,联合组用药后症状恢复的时间也明显少于吡啶斯的明组和强的松组。结论胆碱酯酶抑制剂吡啶斯的明与皮质类固醇联合用药既可减少药物用量,缩短用药时间,又减少眼肌型重症肌无力的复发,减少副作用的发生。(中国眼耳鼻喉科杂志,2006,6:167～169)

Purpose To evaluate the treatment of Ocular Myasthenia Grads in children, to reduce the comphcation and side effect of drugs. Methods Eighty-five cases were divided into three groups, patients in A group were treated with antichohnesterase, patients in B group were treated with prednisone, patients in C group were treated with anticholinesterase and prednisone together. All cases were followed three years. Results A and B group treated with single drug had similar outcomes, C group treated with anticholinesterase and predrtisone together had better results than A or B group. Also, C group had lower relapse ratio than other groups. Conclusion When anticholinesterase and prednisone was used together, short-term drug administration was needed to achieve the goal with less recurrency and complications.