早期放射性肝损伤的CT影像和生化改变

Observations of CT Images and Biochemistry Changes on Radiation-induced Hepatic Injury

目的观察早期放射性肝损伤的CT影像和生化改变。方法三维适形放疗9例腹部肿瘤患者。观察患者放疗前、后生化和肝脏CT影像改变。结果7例患者CT平扫受照肝脏显示为界限清晰的低密度改变,2例合并脂肪肝患者照射区显示为界限清晰的高密度改变。正常肝脏与肝硬化肝脏放射性损伤动态CT增强表现不同。患者疗后ALT、AST、AKP、GGT均较治疗前升高。结论放射性肝损伤CT影像改变与肝脏原发疾病相关,肝功能改变与影像改变一致。

Objective To recognize the acute irradiation-induced hepatic injury,Methods Nine patients with abdominal neoplasm were treated with conformal radiotherapy,Changes of biochemistry and hepatic CT images were observed.Results Hypodensity area of liver on noncontrast CT was observed in 7 patients after delivered conformal radiotherapy,Two patients with fatty infiltration of the liver,CT showed relatived increased density in the treatment portal,Enhanced pattern of irradiation-induced hepatic discase are different between normal liver and cirrhosis liver,Conclusion CT appearance of irradiation-induced hepatic injury is related to primary live disease,comp[anied by change of liver biochemistry.