急性冠脉综合征患者血清妊娠相关血浆蛋白A测定

Determination of serum pregnancy-associated plasma protein-A

目的:检测急性冠脉综合征(ACS)患者血清妊娠相关血浆蛋白A(PAPP -A),并以冠状动脉造影(CAG)评价其冠状动脉病变程度。方法:ACS42例(急性心肌梗死(AMI)19例,不稳定型心绞痛(UAP)23例),稳定型心绞痛(SAP)20例。另设对照14例,均行CAG排除冠心病。采用ELISA测定各组血清PAPP A水平。采用CAG计数冠状动脉病变支数并对冠脉狭窄程度进行评分。结果:ACS组血清PAPP- A水平((19.5±7.8)mIU/L)高于SAP组((8.3±4.7)mIU/L)和对照组((7.6±2.7)mIU/L),P<0.01,SAP组与对照组之间差异无统计学意义(P>0.05)。血清PAPP- A水平与冠状动脉病变血管评分无相关性(P>0.05)。结论:血清PAPP- A水平可作为ACS诊断的辅助指标。

Aim： To determine the serum pregnancy-associated plasma protein-A （PAPP-A） and evaluate the severity of coronary artery lesion by coronary angiography in patients with acute coronary syndrome （ACS）. Methods：The levels of PAPP-A were measured by ELISA method in 62 patients with coronary heart disease （CHD） diagnosed by coronary angiography （CAG） , including 42 patients with ACS and 20 stable angina peetoris （SAP） patients, and 14 non-CHD patients excluded by CAG as control. Results： The concentration of PAPP-A in ACS, SAP and the control group was （ 19.5 ± 7.8 ） mIU/L, （8.3 ± 4.7） mIU/L and （7.6 ± 2.7） mIU/L, respectively . There were statistical differences between SAP and ACS group （P 〈 0.01 ） , while there was no statistical difference between SAP and the control group. No correlation between the level of PAPP-A and Jenkins scores was found. Conclusion ： Serum PAPP-A can be used as an indicator in diagnosis of ACS.