前列腺炎性疼痛与脊髓胶质细胞活化关系的初步研究

Primary study on the relationship between pain of prostatic and activation of glia cells in spinal cord

目的探讨前列腺炎性疼痛与脊髓胶质细胞活化的关系。方法用完全弗氏佐剂(CFA)刺激SD大鼠前列腺,用免疫组织化学技术对不同时间段大鼠相应脊髓节段(L6和S1)星形胶质细胞和小胶质细胞活化情况进行检测。结果CFA刺激大鼠前列腺后3、10、28天,L6、S1脊髓背角浅层和深层星形胶质细胞和小胶质细胞的活化与对照组相比均显著增加。结论胶质细胞活化在前列腺炎性疼痛的神经病理过程可能具有重要作用。

Objective To explore the relationship between pain of prostatitis and activation ot gila cells in spinal cord. Methods To investigate the activation of astroglia cells and microglia cells in spinal cord after irritation of the prostate of the rats with complete Freund＇s adjuvant （CFA） at different time using immunohistochemical staining. Results Activation of astroglia cells and microglia cells were significantly increased in deeper laminae and superficial laminae of the dorsal horn of L6-S1 spinal cord on the third day, tenth day and twentyeighth day after CFA irritation of the prostate, and the most obvious activation occurred on the tenth day. Conclusions Activation of glia cells in spinal cord may play an important role in the neuropathological process of the pain of prostatic inflammation. The molecular mechanisms should he further explored.