中枢神经细胞瘤全基因组的比较基因组杂交分析

Genome-Wide Genetic Study on Central Neurocytoma by Comparative Genomic Hybridization

目的研究中枢神经细胞瘤全基因组的遗传学异常,探讨该肿瘤的发病机制。方法应用比较基因组杂交技术,研究10例中枢神经细胞瘤的遗传学改变。结果10例中枢神经细胞瘤中,6例发现有染色体的失衡,主要表现为遗传物质在染色体2p(4/10)、10 q(4/10)和18 q(3/10)上的获得。结论染色体2p、10 q和18 q的遗传学改变很可能与中枢神经细胞瘤的发病机制有关。

Objective To detect the genome-wide genetic alterations in central neurocytoma, and to study the pathogensis of central neurocytoma. Methods Comparative genomic hybridization （CGH） analysis was performed in 10 central neurocytomas. Results Chromosomal imbalances were demonstrated in 6 cases. Overrepresentation of genetic material was detected in 4 cases on Chromosome 2p and 10q, and 3 cases on Chromosome 18q. Conclusion Genetic abnormalities on Chromosome 2p, 10q and 18q may be associated with the pathogenesis of central neurocytoma.