子宫内膜腺癌c-erbB-2的表达及临床意义

Expression and Clinical Significance of c-erbB-2 in Endometrial Carcinoma

目的探讨c-erbB-2在子宫内膜腺癌组织中的表达及其临床意义。方法采用SP法对52例子宫内膜样腺癌标本进行c-erbB-2的检测,分析其表达率与雌激素受体(ER)、孕激素受体(PR)、病理组织学分级和临床分期(肌层浸润)的关系。结果子宫内膜腺癌组织中c-erbB-2、ER、PR的表达率分别是40.4%、59.6%和63.5%。随着子宫内膜腺癌组织学分级、临床分期的升高,c-erbB-2的表达率逐渐升高,而ER、PR的表达率则逐渐下降。c-erbB-2、PR的表达在不同临床分期之间有显著差异(P<0.05),而c-erbB-2的表达与ER、PR的表达均无相关性(P>0.05)。结论c-erbB-2的过度表达与肿瘤的侵袭性有关,是评估子宫内膜癌预后的重要指标。

Objective To investigate the expression and clinical significance of c-erbB-2 in endometrial carcinoma. Methods The expressions of c-erbB-2, estrogen receptor（ER） and progesterone receptor（PR） in 52 patients with endometrial carcinoma were detected with SP immunohistochemical method. Results The positive ratios of c-erbB-2, ER and PR were 40.4% , 59.6% and 63.5% , respectively. With the advances of tumor histological grade and clinical stage （the depth of myometrial invasion） , the positive expression of c-erbB-2 increased, but those of ER and PR decreased. The positive expressions of c-erbB-2 and PR were associated with clinical stages （P 〈 0.05）. No correlation was found between the expressions of c-erbB-2 and ER or PR （ P 〉 0.05）. Conclusion Overexpression of c-erbB-2 is associated with tumor invasion, c-erbB-2 appears to be an important prognostic factor.