肺大细胞癌62例临床分析

A Clinical Review of 62 Cases with Large Cell Lung Cancer

目的:探讨肺大细胞癌的临床特点及预后因素。方法:对1954年1月～2000年12月在我院接受手术的62例肺大细胞癌患者临床资料进行分析。结果:肺大细胞癌总体1年生存率64.5%(40/62);3年生存率30.6%(15/49);5年生存率21.4%(9/42);其生存率明显高于腺鳞癌和小细胞癌;较鳞癌和腺鳞癌低;影响预后的因素主要为年龄≥或<55岁(P=0.022)、CT示纵隔淋巴结是否肿大(P=0.038)、支气管断端是否阴性(P=0.013)、淋巴结分期(P=0.045)、TNM分期(P=0.011)。结论:肺大细胞癌生存率低,影响其预后的主要因素为淋巴结转移情况、年龄及支气管断端是否阳性。

Objective： To study the clinic characteristics and prognostic factors of large cell lung cancer. Methods： Clinic data of 62 inpatient cases in Cancer Hospital of Tianjin Medical University, from 1954-2000, were retrospectively reviewed. Results： The total 1-year survival rate was 64.5%, 3- year survival rate was 30.6% and the 5-year .survival rate was 21.4%. The survival rates were higher than that of adenosquamous carcinoma and small cell carcinoma patients and were lower than that of squamous carcinoma and adenocarcinoma; The main prognostic factors were age （P=0.022）, bronchial stump （P=0.013）, N stage （P=0.045） and TNM stage （P=0.011）. Conclusions： The survival rate of large cell cancer was low. The main prognostic factors were lymph node status, age, bronchial stump, TNM stage.