可注射性骨组织工程材料不饱和聚磷酸酯的交联特性

CROSSLINKING CHARACTERISTICS OF UNSATURATED POLYPHOSPHOESTER FOR USING AS AN INJECTABLE BONE TISSUE ENGINEERING SCAFFOLD MATERIAL

合成了主链重复结构单元中含不饱和双键的聚磷酸酯,利用FT-IR及NM R对其进行了表征。研究了聚合物分子量、交联剂N-乙烯基吡咯烷酮与引发剂过氧化苯甲酰的含量对最高交联温度、固化时间、压缩强度及压缩模量的影响。研究表明,体系的最高交联温度在41.1℃~82.3℃,低于骨修复材料甲基丙烯酸甲酯的最高交联温度97℃。引发剂含量的增加能够加快体系交联固化。提高分子量以及交联剂与引发剂的含量都能增加交联产物的压缩强度及压缩模量,四种配方所得交联产物的压缩强度为3.3M Pa^11.0 M Pa,压缩模量为4.9 M Pa^101.9 M Pa,接近松质骨的水平。因此,U PPE有可能成为一类新型的可注射性骨组织工程支架材料。

Unsaturated polyphosphoester（UPPE） containing unsaturated olefinic bonds in repeat units was synthesized and characterized by FT-IR and NMR. The effect of UPPE molecular weight, NVP/UPPE ratio, BPO/UPPE ratio on the crosslinking temperature, setting time, compressive strength and compressive modulus was investigated. The maximum crosslinking temperature was between 41.1℃ to 82. 3 ℃ which was lower than that of 97℃ for poly（methyl methacrylate） bone cement. The setting time was strongly affected by BPO/UPPE ratio and decreased rapidly with increasing BPO/UPPE ratio. The compressive strength and compressive modulus values increased with increasing NVP/UPPE ratio, UPPE molecular weight and BPO/ UPPE ratio. For all formulations, the compressive strength values were between 3. 3 MPa to 11.0 MPa, and the compressive modulus values were between 4.9 MPa to 101.9 MPa. These date suggested that UPPE is a potential injectable bone tissue engineering scaffold Material with acceptable handling characteristics.