慢性增强体外反搏猪模型的建立

Establishment of a pig model of chronic ally enhanced external counterpulsation

目的初步建立猪慢性体外反搏模型。方法12头猪,戊巴比妥钠(≤30mg/kg·b.w.)和速眠新Ⅱ(≤0.1ml/kg·b.w.)联合麻醉,取侧卧位,0.025～0.04MPa/cm2的压力进行反搏,2h/次,隔日1次,共计36h。结果所有动物均成功完成了反搏,联合应用戊巴比妥钠和速眠新Ⅱ取得了良好麻醉效果,减少了各自的用量,且对动物的脏器功能没有产生不良影响。结论成功建立了猪慢性体外反搏模型,在猪慢性体外反搏时我们推荐戊巴比妥钠与速眠新Ⅱ联合麻醉。

Objective To establish a pig model of chronic external counterpulsation. Methods Twelve pigs were anaesthetized with sodium pentobarbital （≤ 30 mg/kg, b.w.） and 846 mixture （≤ 0.1 ml/kg·b·w.） and counterpulsed in a lateral position for 2 h every two days （totally 36 h） with 0.025 to 0.04 MPa/cm^2 pressure. Results External counterpulsation was successfully completed in all the animals. Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera （the liver, kidney and heart, etc）, Conclusion The pig model of chronic external counterpulsation has been successfuUy established. Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.